Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia
نویسندگان
چکیده
منابع مشابه
Re: Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.
BACKGROUND The development of noninvasive screening tests is important to reduce mortality from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA methylation from exfoliated cancer cells in feces. METHODS We first analyzed methylation of the RASSF2 and SFRP2 gene promoters from 788 primary gastric and colorectal tissue specimens to determine whether methylation p...
متن کاملDNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus.
PURPOSE Endoscopic surveillance of Barrett's esophagus is problematic because dysplasia/early-stage neoplasia is frequently invisible and likely to be missed because of sampling bias. Molecular abnormalities may be more diffuse than dysplasia. The aim was therefore to test whether DNA methylation, especially on imprinted and X-chromosome genes, is able to detect dysplasia/early-stage neoplasia....
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2009
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djp265